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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B2
All Species:
20.3
Human Site:
S133
Identified Species:
40.61
UniProt:
P37059
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P37059
NP_002144.1
387
42785
S133
R
T
C
S
P
R
L
S
V
L
Q
M
D
I
T
Chimpanzee
Pan troglodytes
XP_511130
387
42727
S133
R
T
C
S
P
R
L
S
V
L
Q
M
D
I
T
Rhesus Macaque
Macaca mulatta
XP_001111794
386
41825
A131
R
S
G
H
C
T
P
A
W
V
T
E
L
D
S
Dog
Lupus familis
XP_546810
382
41989
S134
R
T
C
S
K
R
L
S
V
L
Q
M
D
I
T
Cat
Felis silvestris
Mouse
Mus musculus
P51658
381
41817
S134
K
H
C
S
E
R
L
S
V
L
Q
M
D
V
T
Rat
Rattus norvegicus
Q62730
381
41949
S134
K
N
C
S
E
R
L
S
V
L
Q
M
D
V
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508240
378
41961
A135
Q
M
D
V
T
K
P
A
Q
V
K
E
A
Y
R
Chicken
Gallus gallus
Q5ZJZ5
339
38218
N109
R
M
R
T
V
Q
L
N
V
C
D
S
K
E
V
Frog
Xenopus laevis
NP_001086062
388
43271
T137
K
I
C
S
D
N
L
T
I
I
Q
M
D
L
T
Zebra Danio
Brachydanio rerio
NP_997885
400
44225
Q132
Q
V
D
I
T
Q
P
Q
Q
V
Q
Q
A
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
K95
Q
E
L
E
R
V
K
K
D
L
L
A
L
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
K133
A
R
C
S
P
R
L
K
L
L
Q
M
D
L
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
71.5
66.6
N.A.
59.1
61.2
N.A.
52.4
29.2
39.1
40.5
N.A.
22.7
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
81.1
77
N.A.
74.1
75.4
N.A.
67.6
45.9
55.1
57.5
N.A.
38.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
6.6
93.3
N.A.
73.3
73.3
N.A.
0
20
46.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
33.3
93.3
N.A.
86.6
86.6
N.A.
33.3
40
80
33.3
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
38.5
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
54
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
17
0
0
0
9
17
0
0
% A
% Cys:
0
0
59
0
9
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
17
0
9
0
0
0
9
0
9
0
59
17
0
% D
% Glu:
0
9
0
9
17
0
0
0
0
0
0
17
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
9
0
9
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
9
0
0
0
0
9
9
0
0
0
25
0
% I
% Lys:
25
0
0
0
9
9
9
17
0
0
9
0
9
0
0
% K
% Leu:
0
0
9
0
0
0
67
0
9
59
9
0
17
25
9
% L
% Met:
0
17
0
0
0
0
0
0
0
0
0
59
0
0
0
% M
% Asn:
0
9
0
0
0
9
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
25
0
25
0
0
0
0
0
0
0
0
% P
% Gln:
25
0
0
0
0
17
0
9
17
0
67
9
0
0
0
% Q
% Arg:
42
9
9
0
9
50
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
9
0
59
0
0
0
42
0
0
0
9
0
0
9
% S
% Thr:
0
25
0
9
17
9
0
9
0
0
9
0
0
0
59
% T
% Val:
0
9
0
9
9
9
0
0
50
25
0
0
0
17
17
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _